Pain sensitivity in patients with schizophrenia: a systematic review and meta-analysis.

BACKGROUND: Alterations in pain perception have been observed in people diagnosed with schizophrenia. Some research suggests the existence of a possible hyposensitivity, while others describe a hypersensitivity to pain in people with schizophrenia. In summary, the studies present contradictory results.

Sensibilidad al dolor en pacientes con esquizofrenia: una revisión sistemática y metaanálisis / Pain sensitivity in patients with schizophrenia: a systematic review and meta-analysis

Introducción: En personas diagnosticadas de esquizofrenia se han observado alteraciones en la percepción del dolor.Algunas investigaciones sugieren la existencia de una posiblehiposensibilidad, mientras que otras describen una hipersensibilidad al dolor en personas con esquizofrenia. En definitiva, los estudios presentan resultados contradictorios.Método. Se ha llevado a cabo una revisión sistemática deestudios experimentales y comparativos en 5 bases de datosdiferentes, incluyendo aquellos estudios que evalúan el dolorinducido de manera experimental mediante métodos físicosy comparando los resultados con un grupo control sano. Posteriormente, se ha llevado a cabo un metaanálisis comparando los pacientes con esquizofrenia con los controles sanos,utilizando un modelo de efectos aleatorios.Resultados. Finalmente fueron seleccionados nueve estudios, con un total de 186 participantes diagnosticados deesquizofrenia y 186 controles sanos. En el metaanálisis no seobservaron diferencias significativas en la comparación deanálisis general entre pacientes con esquizofrenia y controlessanos. No obstante, cuando el tipo de estímulo fue estudiadopor separado (mecánico, térmico o eléctrico), se observarondiferencias significativas a favor de una mayor sensibilidad aldolor en los pacientes con esquizofrenia en los estudios queevaluaron el dolor con presión mecánica o isquemia, perono en aquellos que utilizaron métodos térmicos o eléctricos.Conclusiones. El resultado global de nuestra revisión sistemática no respalda la existencia de una alteración en lasensibilidad al dolor en los sujetos con esquizofrenia, aunque un análisis de subgrupos sugiere que cuando el estímulodel dolor es causado por métodos mecánicos, las personascon esquizofrenia presentan una hipersensibilidad al doloren comparación con los controles sanos. Aunque estos resultados son datos novedosos, se requieren más estudios para replicar los resultados. (AU)

Background: Alterations in pain perception have been observed in people diagnosed with schizophrenia. Some researchsuggests the existence of a possible hyposensitivity, while othersdescribe a hypersensitivity to pain in people with schizophrenia.In summary, the studies present contradictory results.Methods. A systematic review of experimental andcomparative studies has been conducted in 5 differentdatabases, including those studies that measure pain experimentally inducing it with physical methods and thatcompares the results with a healthy control group. Afterwards, a meta-analysis was carried out comparing thepatients with schizophrenia to the healthy controls, usingthe random effects model.Results. Nine studies were finally selected, with a totalof 186 participants diagnosed with schizophrenia and 186healthy controls. In the meta-analysis, no significative differences were observed in the general analysis. But when thetype of stimuli was studied separately (mechanical, thermal, or electrical), significative differences in favor of a highersensitivity in the patients with schizophrenia were observedin the studies that measured pain with mechanical pressure or ischemia, not in those that used thermal or electricalmethods.Conclusions. The global result of our systematic reviewdoes not support the existence of an alteration in pain sensitivity in subjects with schizophrenia, although a subgroup analysissuggests that when pain stimulation is caused by mechanicalmethods, people with schizophrenia present hypersensitivity topain compared to healthy controls. Although these results arenovel data, more studies are required to replicate these results. (AU)

Scientific mapping of the research output on hypertension in children and adolescents, 2010-2018.

OBJECTIVE: The area of pediatric hypertension (HTN) research has seen substantial progress over the last two decades, but no bibliometric analysis has yet been undertaken to describe these advances. This study aims to describe the published research examining HTN in children and adolescents from 2000 to 2018. METHODS: Articles were retrieved using PubMed and the Web of Science. Analyses were performed to quantify the evolution of scientific output, identifying the leading journals, authors, and countries as well as the existing collaboration networks. Likewise, we identified the most cited articles, describing their document type, main topic focus, and the age of the patients studied. RESULTS: In total, we identified 8317 articles in the Web of Science. The annual number of publications doubled over the study period. Articles were published in 1415 journals, mainly in the categories of Peripheral & Vascular Diseases and Pediatrics. The USA dominated scientific production in the field. Regarding researcher productivity, the top 202 authors participated in 20% of the articles, and there were 47 stable research clusters, with the largest component made up of 17 authors. Altogether, there were 145 most cited articles, with an irregular annual distribution; about half focus on HTN itself, while the rest study associated disorders and conditions. CONCLUSION: This is the first study to analyze scientific output on HTN in children and adolescents. The snapshot that emerges is of a research area that is growing but is still in a relatively early phase of development.

Efficacy of vitamin D in the treatment of depression: a systematic review and meta-analysis.

Vitamin D is a fat-soluble vitamin that performs multiple functions in the body. In addition to regulating calcium and phosphate levels in the body and contributing to bone mineralization, it participates in various brain and neurocognitive processes. In fact, the deficiency of this vitamin has also been linked to various psychiatric disorders, including depression.

Eficacia de la vitamina D en el tratamiento de la depresión: revisión sistemática y metaanálisis / Efficacy of vitamin D in the treatment of depression: a systematic review and meta-analysis

INTRODUCCIÓN: La vitamina D es una vitamina liposoluble que desempeña múltiples funciones en el organismo. Además de regular los niveles de calcio y fosfato y contribuir a la mineralización ósea, participa en diversos procesos cerebrales y neurocognitivos. De hecho, el déficit de esta vitamina también se ha relacionado con diversos trastornos psiquiátricos, incluida la depresión. OBJETIVO: Revisar si la administración de la vitamina D es eficaz en el tratamiento de la depresión en adultos frente a placebo. METODOLOGÍA: Se realizó una búsqueda bibliográfica en 4 bases de datos (PubMed, Embase, Web of Science-Science Citation Index y Scopus) de ensayos clínicos aleatorizados (ECA) para valorar la eficacia de la vitamina D en adultos con depresión frente a placebo, desde 2013 hasta septiembre de 2019. La medida de resultado utilizada para el cálculo del tamaño del efecto fue la puntuación de los síntomas depresivos. Los tamaños del efecto para los ensayos se calcularon utilizando la diferencia de media estandarizada y la prueba I2 se utilizó para evaluar la heterogeneidad de la muestra. La evaluación crítica de los artículos se realizó mediante la herramienta del funnel plot. RESULTADOS: Un total de 10 ECA que implicaron 1.393 participantes fueron incluidos en el estudio. Dada la heterogeneidad de los estudios se utilizó el modelo de efectos aleatorios. El resultado del metaanálisis indica que la administración oral de vitamina D no obtuvo un efecto significativo en la disminución de las puntuaciones de depresión postintervención. La diferencia de media estandarizada para los datos agrupados fue de -0,91 (intervalo de confianza del 95 %: -2,02 - 0,19).Conclusiones. Este estudio no ha detectado un efecto terapéutico significativo en la administración de la vitamina D en la depresión

INTRODUCTION: Vitamin D is a fat-soluble vitamin that per-forms multiple functions in the body. In addition to regulating calcium and phosphate levels in the body and contributing to bone mineralization, it participates in various brain and neurocognitive processes. In fact, the deficiency of this vitamin has also been linked to various psychiatric disorders, including depression. OBJECTIVE: To review if the administration of vitamin D is effective in the treatment of depression in adults compared to placebo. METHODOLOGY: An electronic search was carried out in 4 databases (PubMed, Embase, Web of Science-Science Citation Index and Scopus) of randomized clinical trials (RCT) to assess the efficacy of vitamin D, in adults with depression compared to placebo, from 2013 to date of search (2019). The outcome measure used for the effect size calculation was the depressive symptom score. The effect sizes for the trials were calculated using the standardized mean difference and the I2 test was used to assess sample heterogeneity. The critical evaluation of the articles was carried out using the funnel plot tool. RESULTS: A total of 10 RCTs involving 1.393 participants were included in the study. Given the heterogeneity of the studies, the random effects model was used. The result of the meta-analysis indicates that oral administration of vita-min D did not have a significant effect on the reduction of post-intervention depression scores. The standardized mean difference for the pooled data was -0,91 (95% confidence interval -2,02 - 0,19). CONCLUSIONS: This study has not detected a significant therapeutic effect in the administration of vitamin D in depression

Information behaviour of the millennial generation: a scoping review of medical residents and their use of social media.

BACKGROUND: Medical residents can offer ideas for new information services, as most of them are 'digital natives', although reviews of the use of social media in health care settings do not provide data on their information behaviour. OBJECTIVE: A scoping review aimed at providing a research map for the information behaviour of medical residents and their use of social media, listing the aspects of the information behaviour studied and the theories and methods used. METHODS: A search was carried out in pubmed, embase, cinahl and lisa in April of 2018, with the results limited to the period from 2010 onwards. RESULTS: Thirty-nine relevant articles from 38 different studies were identified. The presence and use of social media was the most researched aspect, followed by information sharing, the relationships established and, finally, the search for and use of information. These aspects are researched mainly from the point of view of doctor-patient interactions. Only one study incorporated a theory of its design. Surveys were the most frequently used method. CONCLUSION: Research does not delve into medical residents' information behaviour on social media, despite the residents themselves using these media (in the context of everyday life, at least). More research is required.

Investigación pediátrica española financiada: contribución de Anales de Pediatría a su difusión / Spanish funded paediatric research: Contribution of Anales de Pediatría to its dissemination

Objetivo: Identificar la investigación pediátrica española financiada publicada en revistas generales pediátricas incluidas en la WoS (2010-2014) y la de Anales de Pediatría (AP). Explorar la relación de la financiación con el prestigio de las revistas y describir sus condiciones para cumplir los mandatos de acceso abierto. Material y método: La financiación de los artículos publicados en revistas pediátricas generales se identificó utilizando el campo Agencia Financiadora de la WoS y revisando el documento original para AP. Para AP se identificaron las entidades financiadoras de los AF y se valoró la diferencia en la citación de los AF y los no financiados mediante test no paramétrico de Kruskal-Wallis. Se analizó la distribución de los AF y no financiados según cuartil de la revista. De las revistas con AF, se describió su tipo de acceso y su política de autoarchivo utilizando los datos de Sherpa/romeo. Resultados: El 27,5% de los artículos recibió financiación y el 16,6% de los publicados en AP. En estos se identificaron 105 entidades financiadoras (80% nacionales). Los AF de AP no recibieron un número significativamente mayor de citas. El 60% de AF se publicó en revistas de Q1 y Q2. Un 56% de AF se publicaron en revistas de suscripción. Todas las revistas, menos Pediatrics, permiten el autoarchivo de todos los AF pero con embargos de al menos 12 meses. Conclusiones: El papel de AP en la difusión de AF es aun escaso. El embargo de las revistas permite el cumplimiento del mandato español de acceso abierto pero no el europeo (AU)

Objective: To identify Spanish funded paediatric research published in general paediatric journals included in the Web of Science (WoS) from 2010 to 2014) and those published in the Anales de Pediatría. To examine the relationship between funding and the prestige of the journals. To describe the journal conditions to meet the open access criteria. Material and method: Spanish funded paediatric articles (FA) were identified by using the WoS Funding Agency field, and by reviewing the original documents for the Anales de Pediatria (AP). For the FA published in AP the number and kind of funding agencies were identified. The possible differences in citations between FA and non-funded was assessed for articles published in this journal using the Kruskal-Wallis non-parametric test. For general journals, the patterns of distribution of FA and non-FA were investigated according to the quartile of the journal. The journal's self-archiving conditions were described using Sherpa/romeo database. Results: Funding was received for 27.5%, being 16.6% for those published in AP. In these, 105 funding agencies were identified, with 80% being national. The FA published in AP did not receive significantly more citations. In general journals, the presence of FA is greater in Q1 and Q2 journals. More than half (56%) of articles were published in subscription journals. All journals that publish FA allow self-archiving in repositories, but with embargos of at least 12 months. Conclusions: The role of AP in the dissemination of FA is still limited. Embargos in self-archiving permits compliance of Spanish open access mandate, but may hinder compliance in Europe (AU)

[Spanish funded paediatric research: Contribution of Anales de Pediatría to its dissemination]. / Investigación pediátrica española financiada: contribución de Anales de Pediatría a su difusión.

OBJECTIVE: To identify Spanish funded paediatric research published in general paediatric journals included in the Web of Science (WoS) from 2010 to 2014) and those published in the Anales de Pediatría. To examine the relationship between funding and the prestige of the journals. To describe the journal conditions to meet the open access criteria. MATERIAL AND METHOD: Spanish funded paediatric articles (FA) were identified by using the WoS Funding Agency field, and by reviewing the original documents for the Anales de Pediatria (AP). For the FA published in AP the number and kind of funding agencies were identified. The possible differences in citations between FA and non-funded was assessed for articles published in this journal using the Kruskal-Wallis non-parametric test. For general journals, the patterns of distribution of FA and non-FA were investigated according to the quartile of the journal. The journal's self-archiving conditions were described using Sherpa/romeo database. RESULTS: Funding was received for 27.5%, being 16.6% for those published in AP. In these, 105 funding agencies were identified, with 80% being national. The FA published in AP did not receive significantly more citations. In general journals, the presence of FA is greater in Q1 and Q2 journals. More than half (56%) of articles were published in subscription journals. All journals that publish FA allow self-archiving in repositories, but with embargos of at least 12 months. CONCLUSIONS: The role of AP in the dissemination of FA is still limited. Embargos in self-archiving permits compliance of Spanish open access mandate, but may hinder compliance in Europe.

Contribución de Anales de Pediatría a la visibilidad internacional de la investigación pediátrica española en la Web of Science (2010-2014) / Contribution of Anales de Pediatría to the international visibility of Spanish paediatric research in the Web of Science (2010-2014)

OBJETIVO: Describir el papel de Anales de Pediatría en la difusión de la investigación pediátrica española e identificar las revistas con las que compite internacionalmente. MATERIAL Y MÉTODO: Se identificó la producción pediátrica española y la de Anales de Pediatría recogida en la categoría Pediatrics del Science Citation Index de la WoS (2010-2014) analizando su volumen y tipo documental. De los artículos originales y revisiones (artículos) se estudiaron el año, la citación y el tipo de revista de publicación (revistas generales y especializadas). De las generales, se analizó su productividad de acuerdo con su idioma, posición que ocupa en los JCR de 2012 y accesibilidad a sus contenidos. RESULTADOS: Se identificaron 2.701 trabajos pediátricos españoles que representan el 2,8% de la producción pediátrica mundial. El 68% de los trabajos son artículos que recibieron una media de 4.97 citas/artículo. Anales de Pediatría publicó 965 trabajos contabilizando el 35,8% de la producción pediátrica española y el 1% de la mundial; 439 (45,4%) trabajos fueron artículos que recibieron 1,3 citas por artículo. Se identificaron 106 revistas, 82 especializadas (1.196 artículos) y 24 generales (741 artículos). Anales de Pediatría publicó el 60% de los artículos de las revistas generales. Los 302 artículos restantes se publicaron en revistas generales publicadas en inglés (82,8%), con una posición superior en el ranking del JCR (83,4%) y mayoritariamente de suscripción (73,8%). CONCLUSIONES: Anales de Pediatría contribuye a dar visibilidad internacional a un importante volumen de la producción científica española de pediatría. Los resultados presentados constituyen una foto fija de este papel, que permitirá en un futuro evaluar su evolución y los cambios que en ella se vayan incorporando con la finalidad de mejorar su calidad, posicionamiento y competitividad

OBJECTIVE: To describe the role of Anales de Pediatría in highlighting Spanish paediatric research, and to identify the journals with which it competes internationally. Material and method. Spanish paediatric articles, including those from Anales de Pediatría were identified using the Paediatrics category of the Science Citation Index (2010-2014), and their volume and document type was analysed. For original articles and review articles, the year, the citation and journal of publication was studied. The journals were classified as general and specialised. The productivity of general journals was analysed according to their language, JCR quartile, and article access. RESULTS: A total of 2,701 Spanish paediatric papers were identified, accounting for 2.8% of the paediatrics world output. More than two-thirds (68%) of papers were articles that received an average number of 4.97 citations per article. The 965 papers published in Anales de Pediatría accounted for 38.7% of the Spanish paediatric output, and for 1% of the paediatric world publications. A mean of 1.03 citations per article were received for 439 (45.4%) articles and reviews. Of the 106 journals identified, 82 were classified as specialised (1,196 articles) and 24 as general (741 articles). Anales de Pediatría published 60% of the articles in general journals. The rest of articles (309) were published in general journals published in English (82.8%), with a best position in the JCR ranking (83.4%) and mainly by subscription (73.8%). CONCLUSIONS: Anales de Pediatría plays an important role in providing international visibility to a large volume of Spanish scientific production in paediatrics. The results presented are a still only a snapshot of this role that could be used in the near future for assessing its evolution and the changes that could be made in order to improve its quality, positioning and competitiveness

[Contribution of Anales de Pediatría to the international visibility of Spanish paediatric research in the Web of Science (2010-2014)]. / Contribución de Anales de Pediatría a la visibilidad internacional de la investigación pediátrica española en la Web of Science (2010-2014).

OBJECTIVE: To describe the role of Anales de Pediatría in highlighting Spanish paediatric research, and to identify the journals with which it competes internationally. MATERIAL AND METHOD: Spanish paediatric articles, including those from Anales de Pediatría were identified using the Paediatrics category of the Science Citation Index (2010-2014), and their volume and document type was analysed. For original articles and review articles, the year, the citation and journal of publication was studied. The journals were classified as general and specialised. The productivity of general journals was analysed according to their language, JCR quartile, and article access. RESULTS: A total of 2,701 Spanish paediatric papers were identified, accounting for 2.8% of the paediatrics world output. More than two-thirds (68%) of papers were articles that received an average number of 4.97 citations per article. The 965 papers published in Anales de Pediatría accounted for 38.7% of the Spanish paediatric output, and for 1% of the paediatric world publications. A mean of 1.03 citations per article were received for 439 (45.4%) articles and reviews. Of the 106 journals identified, 82 were classified as specialised (1,196 articles) and 24 as general (741 articles). Anales de Pediatría published 60% of the articles in general journals. The rest of articles (309) were published in general journals published in English (82.8%), with a best position in the JCR ranking (83.4%) and mainly by subscription (73.8%). CONCLUSIONS: Anales de Pediatría plays an important role in providing international visibility to a large volume of Spanish scientific production in paediatrics. The results presented are a still only a snapshot of this role that could be used in the near future for assessing its evolution and the changes that could be made in order to improve its quality, positioning and competitiveness.

[Self-archiving of biomedical papers in open access repositories]. / Autoarchivo de articulos biomedicos en repositorios de acceso abierto.

INTRODUCTION AND DEVELOPMENT: Open-access literature is digital, online, free of charge, and free of most copyright and licensing restrictions. Self-archiving or deposit of scholarly outputs in institutional repositories (open-access green route) is increasingly present in the activities of the scientific community. Besides the benefits of open access for visibility and dissemination of science, it is increasingly more often required by funding agencies to deposit papers and any other type of documents in repositories. In the biomedical environment this is even more relevant by the impact scientific literature can have on public health. However, to make self-archiving feasible, authors should be aware of its meaning and the terms in which they are allowed to archive their works. In that sense, there are some tools like Sherpa/RoMEO or DULCINEA (both directories of copyright licences of scientific journals at different levels) to find out what rights are retained by authors when they publish a paper and if they allow to implement self-archiving. PubMed Central and its British and Canadian counterparts are the main thematic repositories for biomedical fields. In our country there is none of similar nature, but most of the universities and CSIC, have already created their own institutional repositories. CONCLUSION: The increase in visibility of research results and their impact on a greater and earlier citation is one of the most frequently advance of open access, but removal of economic barriers to access to information is also a benefit to break borders between groups.

Autoarchivo de artículos biomédicos en repositorios de acceso abierto / Self-archiving of biomedical papers in open access repositories

Introducción y desarrollo. El acceso abierto es el acceso digital, en línea y libre de barreras económicas, o al menos de algunos derechos de explotación (copyright), a la producción científica o académica de nuestros profesores e investigadores. El autoarchivo o depósito de estos trabajos en repositorios institucionales (vía verde) está cada vez más presente entre las actividades de la comunidad científica. Además de beneficiarse de sus ventajas, los autores son, cada vez con más frecuencia, requeridos por las instituciones financiadoras de la investigación y por las suyas propias para que depositen sus trabajos en repositorios. En el entorno biomédico esto es más necesario, por la repercusión que puede tener en la salud de las personas que los profesionales dispongan o no de la mejor evidencia científica. Para que esto sea posible, los autores deben conocer qué es y cómo funciona un repositorio y deben saber manejar herramientas fáciles como Sherpa/ RoMEO o DULCINEA para averiguar qué derechos retienen como autores y si éstos les permiten llevar a la práctica el autoarchivo. PubMed Central y sus homólogos británico y canadiense son los principales repositorios temáticos del ámbito biomédico. En nuestro país no existe ninguno de naturaleza similar; sin embargo, la mayoría de las universidades y el Consejo Superior de Investigaciones Científicas disponen de un repositorio institucional en funcionamiento. Conclusión. La mayor visibilidad de los resultados de investigación y su repercusión en una mayor y más temprana citación es uno de los beneficios más esgrimidos del acceso abierto, así como la eliminación de las barreras económicas en el acceso a la información contrastada para colectivos habitualmente excluidos (AU)

Introduction and development. Open-access literature is digital, online, free of charge, and free of most copyright and licensing restrictions. Self-archiving or deposit of scholarly outputs in institutional repositories (open-access green route) is increasingly present in the activities of the scientific community. Besides the benefits of open access for visibility and dissemination of science, it is increasingly more often required by funding agencies to deposit papers and any other type of documents in repositories. In the biomedical environment this is even more relevant by the impact scientific literature can have on public health. However, to make self-archiving feasible, authors should be aware of its meaning and the terms in which they are allow to archive their works. In that sense, there are some tools like Sherpa/RoMEO or DULCINEA (both directories of copyright licences of scientific journals at different levels) to find out what rights are retained by authors when they publish a paper and if they allow to implement self-archiving. PubMed Central and its British and Canadian counterparts are the main thematic repositories for biomedical fields. In our country there is none of similar nature, but most of the universities and CSIC, have already created their own institutional repositories. Conclusion. The increase in visibility of research results and their impact on a greater and earlier citation is one of the most frequently advance of open access, but removal of economic barriers to access to information is also a benefit to break borders between groups (AU)

Acceso abierto y revistas médicas españolas / Open access and the Spanish medical journals

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A comparative study of six European databases of medically oriented Web resources.

OBJECTIVES: The paper describes six European medically oriented databases of Web resources, pertaining to five quality-controlled subject gateways, and compares their performance. METHOD: The characteristics, coverage, procedure for selecting Web resources, record structure, searching possibilities, and existence of user assistance were described for each database. Performance indicators for each database were obtained by means of searches carried out using the key words, "myocardial infarction." RESULTS: Most of the databases originated in the 1990s in an academic or library context and include all types of Web resources of an international nature. Five databases use Medical Subject Headings. The number of fields per record varies between three and nineteen. The language of the search interfaces is mostly English, and some of them allow searches in other languages. In some databases, the search can be extended to Pubmed. Organizing Medical Networked Information, Catalogue et Index des Sites Médicaux Francophones, and Diseases, Disorders and Related Topics produced the best results. CONCLUSIONS: The usefulness of these databases as quick reference resources is clear. In addition, their lack of content overlap means that, for the user, they complement each other. Their continued survival faces three challenges: the instability of the Internet, maintenance costs, and lack of use in spite of their potential usefulness.